Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip

J Anat. 2008 Feb;212(2):135-43. doi: 10.1111/j.1469-7580.2007.00845.x. Epub 2007 Dec 17.

Abstract

Cleft lip and palate (CL/P), as is true of many craniofacial malformations in humans, is etiologically complex and highly variable in expression. A/WySn mice are an intriguing model for human CL/P because they develop this dysmorphology with a variable expression pattern, incomplete penetrance and frequent unilateral expression on a homogeneous genetic background. The developmental basis for this variation in expression is unknown, but of great significance for understanding such expression patterns in humans. As a step towards this goal, this study used three-dimensional geometric morphometric and novel high throughput morphometric techniques based on three-dimensional computed microtomography of mouse embryos to analyze craniofacial shape variation during primary palate formation. Our analysis confirmed previous findings based on two-dimensional analyses that the midface in A/WySn embryos, and the maxillary prominence in particular, is relatively reduced in size and appears to be developmentally delayed. In addition, we find that shape variance is increased in A/WySn embryos during primary palate formation compared to both C57BL/6J mice and the F1 crosses between these strains. If the reduction in midfacial growth caused by the Wnt9b hypomorphic mutation pushes A/WySn mice closer on average to the threshold for cleft lip formation, the elevated shape variance may explain why some, but not all, embryos develop the dysmorphology in a genetically homogeneous inbred line of mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cleft Lip / embryology*
  • Cleft Palate / embryology*
  • Craniofacial Abnormalities / embryology*
  • Disease Models, Animal
  • Embryonic Development
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Statistics as Topic
  • Tomography Scanners, X-Ray Computed