In search of novel treatments for peripheral neuropathies and nerve regeneration

Ahmet Höke; Ruifa Mi

In search of novel treatments for peripheral neuropathies and nerve regeneration

Discov Med. 2007 Aug;7(39):109-12.

Authors

Ahmet Höke¹, Ruifa Mi

Affiliation

¹ Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. ahoke@jhmi.edu

PMID: 18093472

Abstract

Currently, we do not have effective therapies aimed at preventing or reversing axonal degeneration seen in peripheral neuropathies. Drug development programs should be aimed at understanding mechanisms of distal axonal degeneration and take into account the critical role Schwann cells play in axonal maintenance and nerve regeneration.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Axons / metabolism
Axons / pathology
Humans
Models, Biological
Nerve Regeneration / physiology*
Peripheral Nervous System Diseases / metabolism*
Peripheral Nervous System Diseases / pathology*
Schwann Cells / metabolism
Schwann Cells / physiology