In search of novel treatments for peripheral neuropathies and nerve regeneration

Discov Med. 2007 Aug;7(39):109-12.


Currently, we do not have effective therapies aimed at preventing or reversing axonal degeneration seen in peripheral neuropathies. Drug development programs should be aimed at understanding mechanisms of distal axonal degeneration and take into account the critical role Schwann cells play in axonal maintenance and nerve regeneration.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Axons / metabolism
  • Axons / pathology
  • Humans
  • Models, Biological
  • Nerve Regeneration / physiology*
  • Peripheral Nervous System Diseases / metabolism*
  • Peripheral Nervous System Diseases / pathology*
  • Schwann Cells / metabolism
  • Schwann Cells / physiology