Apoptotic PS to phagocyte TIM-4: eat me

Immunity. 2007 Dec;27(6):830-2. doi: 10.1016/j.immuni.2007.12.002.

Abstract

Although cells dying by apoptosis expose the classical "eat me" signal phosphatidylserine (PS), a phagocytic transmembrane receptor for PS has proved elusive. Now cell and structural studies (Kobayashi et al. [2007] and Santiago et al. [2007] in this issue of Immunity) implicate the type I molecule TIM-4.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis*
  • Hepatitis A Virus Cellular Receptor 1
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Membrane Proteins / metabolism*
  • Mice
  • Phagocytosis*
  • Phosphatidylserines / metabolism*
  • Receptors, Virus / metabolism*

Substances

  • HAVCR1 protein, human
  • Havcr1 protein, mouse
  • Hepatitis A Virus Cellular Receptor 1
  • Membrane Glycoproteins
  • Membrane Proteins
  • Phosphatidylserines
  • Receptors, Virus
  • TIM-4 protein, mouse
  • TIMD4 protein, human