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Review
. 2008 Jan 1;5(1):11-4.
doi: 10.1513/pats.200704-052VS.

Stem cells in airway smooth muscle: state of the art

Jaime Murphy  1 , Ross Summer, Alan Fine
Affiliations
Review

Stem cells in airway smooth muscle: state of the art

Jaime Murphy et al. Proc Am Thorac Soc. .

Abstract

Very little is known regarding the function, origin, and turnover of airway smooth muscle (ASM). In this article, we discuss the embryological development of ASM, and provide information regarding candidate mesenchymal ASM progenitor cell populations specifically in relation to airway remodeling. This review also highlights the current limitations in studying ASM biology, and underscores the need for novel molecular tools and markers that will refine our understanding of this cell type in lung homeostasis and disease.

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Figures

<b>Figure 1.</b>
Figure 1.
Lung side population (SP) cells give rise to smooth muscle. (Left) Density dot plot of Hoechst stained lung digests. The boxed area represents cells (0.09%) that efflux dye (SP cells). (Right) The CD45− CD31− subtype differentiates into α-tropomyosin–positive cells after collection and culture in smooth muscle media. The CD45+ subgroup and the CD45− CD31+ subgroup do not display this capacity.
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