Regulation of heterotrimeric G protein signaling in airway smooth muscle

Proc Am Thorac Soc. 2008 Jan 1;5(1):47-57. doi: 10.1513/pats.200705-054VS.


Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenergic beta-Agonists / therapeutic use
  • Animals
  • Asthma / drug therapy
  • Asthma / etiology
  • Asthma / metabolism
  • Glucocorticoids / therapeutic use
  • Humans
  • Muscle, Smooth / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*
  • Respiratory System / metabolism*
  • Signal Transduction*


  • Adrenergic beta-Agonists
  • Glucocorticoids
  • Receptors, G-Protein-Coupled