Radiosurgery is to irradiate the small volume targets inside of the cranium with high dose radiation in a single session. Gamma knife radiosurgery has been in use for treatment of pain many years. The first cases which have been treated with radiosurgery technique were trigeminal neuralgia patients. After the first installment of gamma knife in 1968, it has been used for thalamotomy in cancer pain. Nowadays the main indication for gamma knife radiosurgery for pain is trigeminal neuralgia.