Characterization of nanoparticles for therapeutics

Nanomedicine (Lond). 2007 Dec;2(6):789-803. doi: 10.2217/17435889.2.6.789.


Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Chemistry, Pharmaceutical / trends*
  • Drug Carriers / chemistry*
  • Nanomedicine / trends*
  • Nanoparticles / chemistry*
  • Nanoparticles / therapeutic use*
  • Nanoparticles / ultrastructure


  • Drug Carriers