Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban

Magn Reson Chem. 2008 Jan;46(1):99-102. doi: 10.1002/mrc.2122.

Abstract

The complete 1H and 13C NMR assignments are reported for the antithrombotic (21R)- and (21S)-argatroban by 1D and 2D NMR experiments (HSQC, HMBC, NOESY and 1H--1H COSY). Some well-resolved signals could be used for an accurate measurement of the diastereomeric composition of argatroban.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arginine / analogs & derivatives
  • Carbon Isotopes
  • Fibrinolytic Agents* / chemical synthesis
  • Fibrinolytic Agents* / chemistry
  • Hydrogen
  • Magnetic Resonance Spectroscopy*
  • Molecular Structure
  • Pipecolic Acids* / chemical synthesis
  • Pipecolic Acids* / chemistry
  • Stereoisomerism
  • Sulfonamides

Substances

  • Carbon Isotopes
  • Fibrinolytic Agents
  • Pipecolic Acids
  • Sulfonamides
  • Hydrogen
  • Arginine
  • argatroban