Assay of 1,4-dioxane in commercial cosmetic products by HPLC

Farmaco. 1991 Nov;46(11):1365-70.

Abstract

The HPLC assay of 1,4-dioxane in a wide range of commercially available cosmetics containing polyethoxylated surfactants is described. After solid-phase extraction using Bakerbond CN- and Bakerbond C18-cartridges, samples were directly analysed on a LiChrospher CH-8 column with an acetonitrile water eluent and UV detection at 200 nm. Of the total cosmetic products investigated, 48% were found to contain 7.3-85.9 ppm of 1,4-dioxane.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Cosmetics / analysis*
  • Dioxanes / analysis*
  • Spectrophotometry, Ultraviolet

Substances

  • Cosmetics
  • Dioxanes
  • 1,4-dioxane