The limited research on the correlation between partially and fully edentulous patients and temporomandibular dysfunction leads this author to believe that a practitioner could expect 25 to 75% of the patients in need of phase 1 orthotic therapy to be in one of these two groups. Unfortunately, most of the literature on orthotic therapy documents cases with a full complement of natural teeth. This chapter gives a systematic approach to the fabrication and insertion of orthotics on and over full and partial dentures.