Anti-aldosteronergic effect of torasemide

Eur J Pharmacol. 1991 Nov 26;205(2):145-50. doi: 10.1016/0014-2999(91)90812-5.

Abstract

The diuretic actions of torasemide and furosemide were studied in normotensive rats and in deoxycorticosterone acetate (DOCA)-saline-loaded hypertensive rats. Torasemide (0.3-3 mg/kg) and furosemide (3-30 mg/kg) had a dose-dependent and significant diuretic action in normotensive rats. Potassium retention was only observed in the case of torasemide. Torasemide also had a dose-dependent and significant diuretic action in DOCA-saline-loaded hypertensive rats, whereas furosemide did not. Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. In vivo aldosterone receptor binding was determined to test the possible anti-aldosteronergic effect of torasemide. Torasemide inhibited the binding of aldosterone to its receptor in the cytoplasmic fraction of rat kidney in a dose-dependent manner, while furosemide produced no effect. These results suggest strongly that an anti-aldosteronergic action of torasemide contributes to producing less kaliuresis.

MeSH terms

  • Administration, Oral
  • Aldosterone / blood
  • Aldosterone / metabolism*
  • Animals
  • Diuretics / pharmacology*
  • Furosemide / pharmacology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Renin / blood
  • Sulfonamides / pharmacology*
  • Torsemide

Substances

  • Diuretics
  • Sulfonamides
  • Aldosterone
  • Furosemide
  • Renin
  • Torsemide