Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
, 4 (6), 871-80

Adjuvant Oils Induce Arthritis in the DA Rat. I. Characterization of the Disease and Evidence for an Immunological Involvement

Affiliations
Comparative Study

Adjuvant Oils Induce Arthritis in the DA Rat. I. Characterization of the Disease and Evidence for an Immunological Involvement

S Kleinau et al. J Autoimmun.

Abstract

An intradermal injection of Freund's incomplete adjuvant oil (FIA) without further additives was shown to induce erosive polyarthritis in dark Agouti (DA) rats, but not in Lewis rats. Histological examination revealed joint inflammation, first with polymorphonuclear cells and synovial hyperplasia, and subsequently, with multinucleated giant cells. Both constituents of FIA, mineral oil and Arlacel A, as well as Pristane oil were arthritogenic, whereas vegetable oil were not. Re-administration of adjuvant oil after recovery failed to induce arthritis, thus making possible a role of specific immunity in this new form of arthritis in rats.

Similar articles

See all similar articles

Cited by 35 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback