Physical training in children with osteogenesis imperfecta

J Pediatr. 2008 Jan;152(1):111-6, 116.e1. doi: 10.1016/j.jpeds.2007.06.029. Epub 2007 Oct 24.


Objective: To study the effects of a physical training program on exercise capacity, muscle force, and subjective fatigue levels in patients with mild to moderate forms of osteogenesis imperfecta (OI).

Study design: Thirty-four children with OI type I or IV were randomly assigned to either a 12-week graded exercise program or care as usual for 3 months. Exercise capacity and muscle force were studied; subjective fatigue, perceived competence, and health-related quality of life were secondary outcomes. All outcomes were measured at baseline (T = 0), after intervention (T = 1), and after 6 and 9 months (T = 2 and T = 3, respectively).

Results: After intervention (T = 1), peak oxygen consumption (VO2peak), relative VO2peak (VO2peak/kg), maximal working capacity (Wmax), and muscle force were significantly improved (17%, 18%, 10%, and 12%, respectively) compared with control values. Subjective fatigue decreased borderline statistically significantly. Follow-up at T = 2 showed a significant decrease of the improvements measured at T = 1 of VO2peak, but VO2peak/kg, Wmax, and subjective fatigue showed no significant difference. At T = 3, we found a further decrease of the gained improvements.

Conclusion: A supervised training program can improve aerobic capacity and muscle force and reduces levels of subjective fatigue in children with OI type I and IV in a safe and effective manner.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Exercise Test
  • Exercise Tolerance*
  • Fatigue / etiology
  • Female
  • Fractures, Bone / etiology
  • Fractures, Bone / therapy
  • Health Status
  • Humans
  • Male
  • Muscle Strength*
  • Osteogenesis Imperfecta / complications
  • Osteogenesis Imperfecta / physiopathology
  • Osteogenesis Imperfecta / therapy*
  • Oxygen Consumption*
  • Physical Education and Training*
  • Quality of Life
  • Severity of Illness Index
  • Treatment Outcome

Associated data

  • ISRCTN/ISRCTN28577651