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, 90 (5), 1656-61

Menstrual Cycle Length Is an Age-Independent Marker of Female Fertility: Results From 6271 Treatment Cycles of in Vitro Fertilization

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Menstrual Cycle Length Is an Age-Independent Marker of Female Fertility: Results From 6271 Treatment Cycles of in Vitro Fertilization

Thomas Brodin et al. Fertil Steril.

Abstract

Objective: To investigate whether menstrual cycle length correlates with success rates at IVF/intracytoplasmic sperm injection (ICSI) and could be used as a marker of ovarian reserve.

Design: Prospective observational study.

Setting: Private infertility centre.

Patient(s): A total of 6271 IVF/ICSI treatment cycles.

Intervention(s): Self-reported mean number of menstrual days during the last year was recorded before initiation of IVF/ICSI treatment.

Main outcome measure(s): Relations between menstrual cycle length and pregnancy and delivery rates.

Result(s): Increasing age was associated with a subtle shortening of mean menstrual cycle length. Menstrual cycle length correlated linearly with pregnancy and delivery rates, even after age adjustment. The chance of delivery after IVF/ICSI was almost doubled for women with a menstrual cycle length >34 days compared with women with a menstrual cycle length <26 days. Menstrual cycle length was also significantly associated with ovarian response to FSH/hMG stimulation and embryo quality.

Conclusion(s): Mean menstrual cycle length is highly related to success rates in assisted reproduction, independently of age. A precise menstrual cycle history could be used as a simple marker of ovarian reserve.

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