Increased risk of hip fracture among men with CKD

Am J Kidney Dis. 2008 Jan;51(1):38-44. doi: 10.1053/j.ajkd.2007.08.019.


Background: Patients with chronic kidney disease (CKD) have disturbances in mineral metabolism. Those requiring dialysis therapy are at substantially increased risk of fracture. However, fracture risk in patients with CKD not requiring dialysis has not been well studied.

Study design: Retrospective cohort.

Setting & participants: We identified men who sought care at 8 Veterans Affairs Medical Centers located in the Northwest from July 1999 to March 2006 who had a glomerular filtration rate (GFR) less than 60 mL/min/1.73 m(2). Patients who received long-term dialysis therapy or had a previous organ transplant, diagnosis of cancer, or history of hip fracture were excluded. Proportional hazards models were used to estimate the association of GFR stage with relative risk of hip fracture.

Predictor: GFR estimated on the basis of 2 or more consecutively abnormal outpatient serum creatinine measurements during a 6-month period.

Outcome: Hip fracture ascertained from patient medical records.

Results: In 33,091 veterans, 176 hip fractures were identified. After adjustment for age, body mass index, diabetes, and use of selected medications, relative risks of hip fracture for men with a GFR of 30 to 59 and 15 to 29 mL/min/1.73 m(2) were 1.28 (95% confidence interval, 0.88 to 1.66) and 3.98 (95% confidence interval, 2.25 to 7.74), respectively.

Limitations: Retrospective study of men only.

Conclusions: These results suggest that the risk of hip fracture in men with CKD stage 4 is increased to a degree similar to that of dialysis patients.

Publication types

  • Comparative Study
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Glomerular Filtration Rate / physiology
  • Hip Fractures / epidemiology*
  • Hip Fractures / etiology*
  • Hip Fractures / physiopathology
  • Humans
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / epidemiology*
  • Kidney Failure, Chronic / physiopathology
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors