Incremental costs of post-liver transplantation complications

J Am Coll Surg. 2008 Jan;206(1):89-95. doi: 10.1016/j.jamcollsurg.2007.06.292. Epub 2007 Sep 18.


Background: Complications after liver transplantation are common and expensive. The incremental costs of adult posttransplantation liver transplantation complications and who pays for these complications (center or payor) is unknown.

Study design: We reviewed the medical and financial records (first 90 postoperative days) of all adult liver transplant recipients at our center between July 1, 2002, and October 30, 2005 (N = 214). The association of donor, recipient, and financial data points (total costs, reimbursements, and profits) was assessed using standard univariable analyses. The incremental costs of complications were determined with multiple linear regression models to control for the costs inherent to donor and recipient characteristics.

Results: Univariate analyses demonstrated that both total hospital costs and reimbursements were substantially increased in patients with several different complications. Multiple linear regression analysis, controlling for recipient (age, gender, race, and laboratory Model for End-Stage Liver Disease [MELD]) and donor factors (donor risk index), noted that increased hospital costs and hospital reimbursements were independently associated with laboratory MELD (incremental costs of $3,368 and $2,787, respectively, per MELD point) and pneumonia ($83,718 and $68,214, respectively). A negative profit margin for the medical center was independently associated with peritonitis ($21,760). Commercial insurance was associated with no changes in total costs when compared with public insurer, but it was associated with decreased reimbursement and profit.

Conclusions: The incremental costs of complications in liver transplantation are high for both the medical center and payor, but medical center profits are not affected substantially. The payor bears the financial burden for post-liver transplantation complications.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Costs and Cost Analysis
  • Female
  • Follow-Up Studies
  • Hospital Charges / trends*
  • Hospital Costs / trends*
  • Humans
  • Liver Failure / surgery
  • Liver Transplantation / adverse effects*
  • Liver Transplantation / economics
  • Male
  • Middle Aged
  • Postoperative Complications / economics*
  • Regression Analysis
  • Retrospective Studies
  • United States