Abstract
A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Drug Design
-
Humans
-
Integrin alpha4beta1 / blood
-
Integrin alpha4beta1 / drug effects*
-
Leukocytes / drug effects*
-
Membranes, Artificial
-
Molecular Mimicry
-
Molecular Structure
-
Oligopeptides / blood
-
Oligopeptides / chemical synthesis*
-
Phenylpropionates / chemistry*
-
Polyvinyls / chemistry
-
Polyvinyls / metabolism
-
Structure-Activity Relationship
Substances
-
3-(4-azidophenyl)propionic acid
-
3-(5-amino-2-hydroxy)phenyl-propionic acid
-
Integrin alpha4beta1
-
Membranes, Artificial
-
Oligopeptides
-
Phenylpropionates
-
Polyvinyls
-
leucyl-aspartyl-valine
-
polyvinylidene fluoride