Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography

Opt Lett. 2008 Jan 1;33(1):22-4. doi: 10.1364/ol.33.000022.


We describe a novel instrument capable of acquiring, simultaneously, adaptive optics enhanced scanning laser ophthalmoscopy and optical coherence tomography (OCT) images of the human cone mosaic in vivo. The OCT system is based on transversal scanning of the sample with a line scan rate of 14 kHz, approximately 20 times faster than a previously reported instrument. We demonstrate the capability of this instrument with the measurement of the human cone spacing in perifoveal retina.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Humans
  • Image Enhancement / instrumentation*
  • Microscopy, Confocal / instrumentation*
  • Ophthalmoscopes*
  • Optics and Photonics / instrumentation
  • Retinal Cone Photoreceptor Cells / cytology*
  • Sensitivity and Specificity
  • Subtraction Technique / instrumentation*
  • Tomography, Optical Coherence / instrumentation*