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Review
, 29 Suppl 2, S61-5

[Antipsychotics, Anticonvulsants, Antiadrenergics and Other Drugs: What to Do When Posttraumatic Stress Disorder Does Not Respond to Selective Serotonin Reuptake Inhibitors?]

[Article in Portuguese]
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Review

[Antipsychotics, Anticonvulsants, Antiadrenergics and Other Drugs: What to Do When Posttraumatic Stress Disorder Does Not Respond to Selective Serotonin Reuptake Inhibitors?]

[Article in Portuguese]
William Berger et al. Braz J Psychiatry.

Abstract

Objectives: In this narrative review, we aimed to describe different pharmacological strategies for the treatment of patients with post-traumatic stress disorder who display different levels of intolerance, resistance, refractoriness, or who are unable to take to antidepressants, especially serotonin reuptake inhibitors.

Method: We searched the ISI web of science and the PubMed for original studies focusing in the treatment of PTSD in different clinical scenarios.

Results: Preliminary evidence pointed towards the efficacy of drugs such as risperidone, olanzapine, lamotrigine and prazosin as strategies to be employed in the above mentioned clinical scenarios. The choice of a specific "second line" drug should take into account not only symptoms, but also pattern of comorbidities, previous response to other treatments, pharmacological interactions, side-effects, and patient's physical conditions.

Conclusions: Future randomized controlled trials should be performed in order to unveil which drugs should be prescribed in the absence of adequate treatment and response to serotonin reuptake inhibitors.

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