Chronic toxicity risk after radiotherapy for patients with systemic sclerosis (systemic scleroderma) or systemic lupus erythematosus: association with connective tissue disorder severity

Radiother Oncol. 2008 Apr;87(1):127-31. doi: 10.1016/j.radonc.2007.11.031. Epub 2007 Dec 26.

Abstract

No method reliably identifies which patients with connective tissue disorders are at greatest risk of radiotherapy-related complications. Building on our prior experience, we postulated that disease severity, as measured by the number of organ systems involved, may predict chronic radiation toxicity risk.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / pathology
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Neoplasms / radiotherapy*
  • Radiotherapy / adverse effects*
  • Risk
  • Scleroderma, Systemic / complications*
  • Scleroderma, Systemic / pathology
  • Severity of Illness Index