Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset

Brain Res. 1991 Dec 13;567(1):127-32. doi: 10.1016/0006-8993(91)91444-6.


Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine and, to a lesser extent, of its metabolites in the striatum and in some extrastriatal regions. There was also a profound loss of serotonin in the striatum and in all of the extrastriatal regions analyzed, which was still highly significant 6 months after discontinuation of MPTP treatment. The results suggest that the selected dosage schedule produces a widespread and lasting neuronal degeneration closely resembling the neurochemical pathology of Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Callithrix
  • Dopamine / metabolism*
  • Drug Administration Schedule
  • Female
  • Homovanillic Acid / metabolism
  • MPTP Poisoning*
  • Male
  • Organ Specificity
  • Reference Values
  • Serotonin / metabolism*


  • 3,4-Dihydroxyphenylacetic Acid
  • Serotonin
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Dopamine
  • Homovanillic Acid