Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 9 (12), 767-76

Natural Products as Leads to Anticancer Drugs

Affiliations
Review

Natural Products as Leads to Anticancer Drugs

M Gordaliza. Clin Transl Oncol.

Abstract

Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of medicine, pharmacy and biology. Within the sphere of cancer, a number of important new commercialised drugs have been obtained from natural sources, by structural modification of natural compounds, or by the synthesis of new compounds, designed following a natural compound as model. The search for improved cytotoxic agents continues to be an important line in the discovery of modern anticancer drugs. The huge structural diversity of natural compounds and their bioactivity potential have meant that several products isolated from plants, marine flora and microorganisms can serve as "lead" compounds for improvement of their therapeutic potential by molecular modification. Additionally, semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects. These processes, complemented with high-throughput screening protocols, combinatorial chemistry, computational chemistry and bioinformatics are able to afford compounds that are far more efficient than those currently used in clinical practice. Combinatorial biosynthesis is also applied for the modification of natural microbial products. Likewise, advances in genomics and the advent of biotechnology have improved both the discovery and production of new natural compounds.

Similar articles

See all similar articles

Cited by 123 PubMed Central articles

See all "Cited by" articles

References

    1. Methods Find Exp Clin Pharmacol. 2007 May;29(4):303-11 - PubMed
    1. J Clin Oncol. 1999 Jun;17 (6):1751-9 - PubMed
    1. Free Radic Biol Med. 2007 Sep 15;43(6):968-75 - PubMed
    1. IUBMB Life. 2002 Apr-May;53(4-5):269-74 - PubMed
    1. J Med Chem. 2007 Oct 18;50(21):5183-92 - PubMed

Publication types

LinkOut - more resources

Feedback