Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers

Eur J Clin Pharmacol. 1991;41(6):615-7. doi: 10.1007/BF00314996.


The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline. In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance.

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Alkaloids*
  • Benzodioxoles
  • Biological Availability
  • Drug Therapy, Combination
  • Humans
  • Middle Aged
  • Piperidines / pharmacology*
  • Polyunsaturated Alkamides
  • Propranolol / administration & dosage
  • Propranolol / pharmacokinetics*
  • Theophylline / administration & dosage
  • Theophylline / pharmacokinetics*


  • Alkaloids
  • Benzodioxoles
  • Piperidines
  • Polyunsaturated Alkamides
  • Propranolol
  • Theophylline
  • piperine