Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity

J Surg Oncol. 2008 Mar 1;97(3):273-7. doi: 10.1002/jso.20930.


Background and objectives: Our objective was to evaluate the clinical significance of angiopoietin-1 (Ang-1) and Ang-2 expression in recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC).

Patients and methods: Formalin-fixed, paraffin-embedded tissues from 40 patients who underwent surgical intervention for local or local-regional recurrent OCSCC between 1995 and 2005 were immunohistochemically analyzed for Ang-1 and Ang-2 expression.

Results: The recurrent TNM staging classified 5 patients as stage I, 4 as stage II, 2 as stage III, and 29 as stage IV. The actuarial 3-year disease-free survival rate was 43.1% with a mean follow-up of 18.4 months (ranged 1-70 months). High expression of Ang-1 was significantly correlated with positive nodal stage (P = 0.041). Patients with more advanced recurrent stage of the tumors (P = 0.0036) and high expression of Ang-2 (P = 0.045) showed lower actuarial 3-year disease-free survival. However, Cox's regression analysis revealed that only recurrent tumor (rT) stage was an independent prognostic factor for survival (P = 0.019, 95% CI = 1.473-82.017, relative risk = 10.992).

Conclusions: Recurrent OCSCC with high Ang-1 or Ang-2 expression in the tumor bed exhibits aggressive tumor behavior. However, the salvage outcome depends on the rT stage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Angiopoietin-1 / metabolism*
  • Angiopoietin-2 / metabolism*
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / metabolism*
  • Mouth Neoplasms / mortality
  • Mouth Neoplasms / pathology
  • Neoplasm Recurrence, Local / metabolism*
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Pilot Projects
  • Predictive Value of Tests
  • Survival Analysis


  • ANGPT1 protein, human
  • Angiopoietin-1
  • Angiopoietin-2