The association between coeliac disease and cardiovascular disease

Aliment Pharmacol Ther. 2008 Mar 15;27(6):514-9. doi: 10.1111/j.1365-2036.2007.03594.x. Epub 2007 Dec 21.


Background: Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear.

Aim: To investigate whether coeliac disease patients have an increased risk of cardiovascular events.

Methods: A community-based cohort study using a record-linkage database. Three hundred and sixty-seven coeliac patients identified by a positive antiendomysial antibody test or a diagnosis with small bowel biopsy, and 5537 subjects who were tested and had a negative coeliac immunology, were included in the study.

Results: The crude rates of cardiovascular events were 9.5 per 1000 person-years (95% CI: 4.4-14.6) in the coeliac cohort and 8.9 per 1000 person-years (95% CI: 7.6-10.3) in the antiendomysial antibody-negative cohort. Compared with the antiendomysial antibody-negative cohort, the adjusted relative risk of cardiovascular events for coeliac cohort was 1.9 (95% CI: 1.00-3.60). When we excluded patients who had previous hospitalization for cardiovascular disease, the adjusted relative risk was 2.5 (95% CI: 1.22-5.01). The use of any cardiovascular drugs prior to and after entry to the study were 36% and 29% for the coeliac cohort (P = 0.05), and 34% and 26% for the antiendomysial antibody-negative cohort (P < 0.01).

Conclusion: Our findings suggest that coeliac disease seems to be associated with an increased risk of cardiovascular outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology*
  • Celiac Disease / complications*
  • Celiac Disease / epidemiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Scotland / epidemiology