The Unique Functions of Cardiac Troponin I in the Control of Cardiac Muscle Contraction and Relaxation

Biochem Biophys Res Commun. 2008 Apr 25;369(1):82-7. doi: 10.1016/j.bbrc.2007.12.114. Epub 2007 Dec 26.

Abstract

We review development of evidence and current perceptions of the multiple and significant functions of cardiac troponin I in regulation and modulation of cardiac function. Our emphasis is on the unique structure function relations of the cardiac isoform of troponin I, especially regions containing sites of phosphorylation. The data indicate that modifications of specific regions cardiac troponin I by phosphorylations either promote or reduce cardiac contractility. Thus, a homeostatic balance in these phosphorylations is an important aspect of control of cardiac function. A new concept is the idea that the homeostatic mechanisms may involve modifications of intra-molecular interactions in cardiac troponin I.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Signaling*
  • Heart / physiopathology*
  • Humans
  • Models, Cardiovascular*
  • Myocardial Contraction*
  • Troponin / metabolism*
  • Troponin I / metabolism*

Substances

  • Troponin
  • Troponin I
  • Calcium