Botryolides A-E, decarestrictine analogues from a fungicolous Botryotrichum sp. (NRRL 38180)

J Nat Prod. 2008 Mar;71(3):415-9. doi: 10.1021/np070610d. Epub 2007 Dec 30.

Abstract

Four new decarestrictine analogues (botryolides A-D; 1- 4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D ( 6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1- 5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aspergillus flavus / drug effects
  • Candida albicans / drug effects
  • Crystallography, X-Ray
  • Florida
  • Fungi / chemistry*
  • Fusarium / drug effects
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Staphylococcus aureus / drug effects
  • Sterigmatocystin / chemistry
  • Sterigmatocystin / isolation & purification

Substances

  • Lactones
  • Sterigmatocystin
  • decarestrictine D