Abstract
Four new decarestrictine analogues (botryolides A-D; 1- 4), a biosynthetically related gamma-lactone (botryolide E; 5), and the known compounds decarestrictine D ( 6) and sterigmatocystin have been isolated from cultures of a fungicolous isolate of Botryotrichum sp. (NRRL 38180). The structures of these compounds were determined by analysis of 2D NMR and ESIMS data. The relative configurations of 1- 5 were established on the basis of NMR data and/or X-ray diffraction analysis, while the absolute configuration of 1 was assigned using the modified Mosher method.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aspergillus flavus / drug effects
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Candida albicans / drug effects
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Crystallography, X-Ray
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Florida
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Fungi / chemistry*
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Fusarium / drug effects
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Microbial Sensitivity Tests
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Staphylococcus aureus / drug effects
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Sterigmatocystin / chemistry
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Sterigmatocystin / isolation & purification
Substances
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Lactones
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Sterigmatocystin
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decarestrictine D