Growth and development of children born after in vitro fertilization

Fertil Steril. 2008 Nov;90(5):1662-73. doi: 10.1016/j.fertnstert.2007.09.005. Epub 2007 Dec 27.


Objective: To evaluate growth and development of children born after IVF treatment.

Design: Literature review.

Conclusion(s): At present there is substantial evidence that children born after IVF are at increased risk for adverse perinatal outcome, congenital malformations, and rare epigenetic defects. It is still unclear whether observed health problems originate from the IVF procedure itself or the underlying subfertility problems of the parents. Current follow-up studies regarding postnatal growth and morbidity rates are scarce with conflicting results and other areas of long-term research in children born after IVF are still in its infancy. The importance of the worldwide continuing monitoring of children born after IVF to investigate potential long-term consequences including the development of cardiovascular diseases is therefore highlighted.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / genetics
  • Child
  • Child Development*
  • Congenital Abnormalities / etiology
  • Congenital Abnormalities / genetics
  • Embryonic Development
  • Environment
  • Epigenesis, Genetic
  • Female
  • Fertilization in Vitro / adverse effects*
  • Fetal Development
  • Gene Expression Regulation, Developmental*
  • Genomic Imprinting
  • Humans
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Pregnancy
  • Pregnancy Outcome