AIDS Vaccine: Efficacy, Safety and Ethics

Vaccine. 2008 Jun 6;26(24):3072-7. doi: 10.1016/j.vaccine.2007.11.061. Epub 2007 Dec 17.


Human immunodeficiency virus (HIV) has infected 50 million people worldwide and killed 16 million so far, and the epidemic is still spreading with 16,000 new cases of HIV infection daily and a projection of 100 million infected individuals by the end of the next decade. There is no question that a safe and effective acquired immunodeficiency syndrome (AIDS) vaccine is urgently needed to bring the current AIDS pandemic under control. But, is preventive AIDS vaccine an attainable goal? Unfortunately, the results of many laboratory and clinical studies over the past two decades are not encouraging. We comment on the efficacy, safety and ethics of AIDS vaccine, and the urgent need for a new strategy for AIDS vaccine development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS Vaccines / adverse effects*
  • AIDS Vaccines / immunology
  • AIDS Vaccines / therapeutic use*
  • Consumer Product Safety
  • HIV Envelope Protein gp120 / immunology
  • HIV Infections / prevention & control*
  • HIV-1 / immunology*
  • Humans
  • Vaccination / adverse effects*
  • Vaccination / ethics*
  • Vaccines, Synthetic / adverse effects
  • Vaccines, Synthetic / therapeutic use


  • AIDS Vaccines
  • HIV Envelope Protein gp120
  • Vaccines, Synthetic
  • gp120 protein, Human immunodeficiency virus 1