Field Defects in Progression to Gastrointestinal Tract Cancers

Cancer Lett. 2008 Feb 18;260(1-2):1-10. doi: 10.1016/j.canlet.2007.11.027. Epub 2007 Dec 31.

Abstract

A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenocarcinoma / pathology
  • Animals
  • Apoptosis
  • Bile Acids and Salts / metabolism
  • Bile Duct Neoplasms / pathology
  • Carcinoma, Squamous Cell / pathology
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology*
  • Cholangiocarcinoma / pathology
  • Disease Progression
  • Esophageal Neoplasms / pathology
  • Gastrointestinal Neoplasms / genetics
  • Gastrointestinal Neoplasms / metabolism
  • Gastrointestinal Neoplasms / pathology*
  • Gene Expression Regulation, Neoplastic
  • Genomic Instability
  • Head and Neck Neoplasms / pathology
  • Humans
  • Intestinal Neoplasms / pathology
  • Pancreatic Neoplasms / pathology
  • Precancerous Conditions / genetics
  • Precancerous Conditions / metabolism
  • Precancerous Conditions / pathology*
  • Risk Factors
  • Stomach Neoplasms / pathology

Substances

  • Bile Acids and Salts