Should Anacardium humile St. Hil be used as an antiulcer agent? A scientific approach to the traditional knowledge

Anderson Luiz-Ferreira; Maira Cola-Miranda; Victor Barbastefano; Clélia Akiko Hiruma-Lima; Wagner Vilegas; Alba Regina Monteiro Souza Brito

doi:10.1016/j.fitote.2007.11.006

Should Anacardium humile St. Hil be used as an antiulcer agent? A scientific approach to the traditional knowledge

Fitoterapia. 2008 Apr;79(3):207-9. doi: 10.1016/j.fitote.2007.11.006. Epub 2007 Nov 28.

Authors

Anderson Luiz-Ferreira¹, Maira Cola-Miranda, Victor Barbastefano, Clélia Akiko Hiruma-Lima, Wagner Vilegas, Alba Regina Monteiro Souza Brito

Affiliation

¹ Departamento de Fisiologia e Biofísica, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. a021709@dac.unicamp.br

PMID: 18164871
DOI: 10.1016/j.fitote.2007.11.006

Abstract

The crude methanolic extract (ME) obtained from the leaves of Anacardium humile was evaluated orally at doses of 250-500-1000 mg/kg on gastric lesion on ethanol and piroxicam induced gastric lesions in rodents. All the tested doses significantly inhibited gastric lesions by 56 to 100%. These results seems to support the traditional use of this species in the treatment of gastric diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anacardium*
Animals
Anti-Ulcer Agents / administration & dosage
Anti-Ulcer Agents / pharmacology*
Anti-Ulcer Agents / therapeutic use
Dose-Response Relationship, Drug
Ethanol
Male
Mice
Phytotherapy*
Piroxicam
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Plant Leaves
Rats
Rats, Wistar
Stomach Ulcer / chemically induced
Stomach Ulcer / pathology
Stomach Ulcer / prevention & control*

Substances

Anti-Ulcer Agents
Plant Extracts
Piroxicam
Ethanol