Next-generation sequencing transforms today's biology

Nat Methods. 2008 Jan;5(1):16-8. doi: 10.1038/nmeth1156. Epub 2007 Dec 19.


A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms*
  • Biology / trends*
  • Forecasting
  • Oligonucleotide Array Sequence Analysis / trends*
  • Sequence Analysis, DNA / trends*