Renoprotection with vitamin D: specific for diabetic nephropathy?

Kidney Int. 2008 Jan;73(2):141-3. doi: 10.1038/


Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,25(OH)(2)D(3) on inhibition of the renin-angiotensin system (RAS) in vitro. The authors conclude that the higher activation of the intrarenal RAS is the key factor to induce more severe diabetic nephropathy in VDR(-/-) mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Diabetic Nephropathies / etiology
  • Diabetic Nephropathies / prevention & control*
  • Mesangial Cells / pathology
  • Mice
  • Podocytes / pathology
  • Receptors, Calcitriol / physiology*
  • Renin-Angiotensin System / physiology
  • Vitamin D / physiology*


  • Receptors, Calcitriol
  • Vitamin D