Genotyping of Panamanian Trypanosoma cruzi stocks using the calmodulin 3'UTR polymorphisms

Parasitol Res. 2008 Feb;102(3):523-6. doi: 10.1007/s00436-007-0775-5. Epub 2007 Dec 29.


Mutations in the 3' untranslated region of calmodulin gene have recently been reported to be specific to different Trypanosoma cruzi lineages. In the present report, this molecular marker was used to genotype 24 T. cruzi isolates from humans and vectors from different endemic areas in Panama. The finding of solely T. cruzi I genotype might explain the low morbidity of Chagas' disease in the region when compared to other countries in Latin America.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Animals
  • Base Sequence
  • Calmodulin / genetics*
  • Conserved Sequence
  • Genotype
  • Panama
  • Polymorphism, Genetic*
  • Protozoan Proteins / genetics*
  • Sequence Alignment
  • Sequence Homology, Nucleic Acid
  • Species Specificity
  • Trypanosoma cruzi / genetics*
  • Trypanosoma cruzi / isolation & purification


  • 3' Untranslated Regions
  • Calmodulin
  • Protozoan Proteins