Copper-catalyzed aerobic oxidative amidation of terminal alkynes: efficient synthesis of ynamides

J Am Chem Soc. 2008 Jan 23;130(3):833-5. doi: 10.1021/ja077406x. Epub 2008 Jan 1.


A copper-catalyzed method for the preparation of ynamides has been identified that proceeds via aerobic oxidative coupling of terminal alkynes with various nitrogen nucleophiles, including cyclic carbamates, amides and ureas, and N-alkyl-arylsulfonamides and indoles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aerobiosis
  • Alkynes / chemistry*
  • Amides / chemical synthesis*
  • Catalysis
  • Copper / chemistry*
  • Oxidation-Reduction


  • Alkynes
  • Amides
  • Copper