Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations

Am J Obstet Gynecol. 2008 Jan;198(1):32.e1-7. doi: 10.1016/j.ajog.2007.05.020.


Objective: This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population.

Study design: This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions.

Results: One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001).

Conclusion: In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Cervix Uteri / drug effects
  • Cervix Uteri / pathology*
  • Colposcopy / methods
  • Condoms
  • Confidence Intervals
  • Contraception
  • Contraceptive Devices, Female
  • Female
  • Humans
  • Immunohistochemistry
  • Nonoxynol / administration & dosage*
  • Odds Ratio
  • Probability
  • Reference Values
  • Sexually Transmitted Diseases / prevention & control
  • Spermatocidal Agents / administration & dosage*
  • Vagina / drug effects
  • Vagina / pathology*


  • Spermatocidal Agents
  • Nonoxynol