MAGE-A and NY-ESO-1 expression in cervical cancer: prognostic factors and effects of chemotherapy

Am J Obstet Gynecol. 2008 Jan;198(1):99.e1-7. doi: 10.1016/j.ajog.2007.05.019.


Objective: The aim of this study was to evaluate the prevalence of cancer testis tumor-associated antigens MAGE-A and NY-ESO-1 in cervical cancer and correlate expression patterns with clinicopathologic parameters and prognosis.

Study design: One hundred sixty-two cervical cancer samples from 109 patients who were treated with radical hysterectomy, neoadjuvant chemotherapy, or pelvic disease recurrence were analyzed by immunohistochemistry.

Results: MAGE-A was expressed by 32/94 (34%) and 7/15 (47%) previously untreated and recurrent tumors, respectively. NY-ESO-1 was expressed by 46/94 (49%) and 6/15 (40%) previously untreated and recurrent tumors, respectively. MAGE-A in early stage tumors was correlated to tumor size and lymph node metastases (P = .024 and P = .046, respectively) whereas NY-ESO-1 to tumor grading (P = .039).

Conclusion: Cervical cancer frequently expresses cancer testis tumor-associated antigens. MAGE-A and NY-ESO-1 expression rates are not influenced by systemic therapies. Cancer testis tumor-associated antigens are correlated to common prognostic factors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, Neoplasm / genetics
  • Antigens, Neoplasm / metabolism*
  • Biomarkers, Tumor / analysis*
  • Biopsy, Needle
  • Chemotherapy, Adjuvant
  • Cohort Studies
  • Female
  • Humans
  • Hysterectomy / methods
  • Immunohistochemistry
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Staging
  • Probability
  • Prognosis
  • Sensitivity and Specificity
  • Survival Analysis
  • Tissue Culture Techniques
  • Treatment Outcome
  • Uterine Cervical Neoplasms / drug therapy*
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / surgery


  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • CTAG1B protein, human
  • Membrane Proteins