Cellular location of KMP-11 protein in Trypanosoma rangeli

Vector Borne Zoonotic Dis. Spring 2008;8(1):93-6. doi: 10.1089/vbz.2006.0650.

Abstract

We describe the localization of the KMP-11 protein in the Trypanosoma rangeli parasite determined by immunoelectron microscopy using a monoclonal antibody generated against the Trypanosoma cruzi KMP-11 protein. The data reported herein show that the T. rangeli KMP-11 protein is mainly accumulated in the parasite cytoplasm, the coat, the flagellum, and the flagellar pocket. The high degree of sequence homology between the KMP-11 proteins from both parasites suggests that the KMP-11 protein from T. rangeli, like that of T. cruzi, could also be associated with the parasite cytoskeleton.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Cytoskeletal Proteins
  • Cytoskeleton / immunology*
  • Flagella
  • Membrane Glycoproteins / analysis
  • Membrane Glycoproteins / immunology*
  • Microscopy, Immunoelectron / methods
  • Protozoan Proteins / analysis
  • Protozoan Proteins / immunology*
  • Trypanosoma / metabolism*

Substances

  • Antibodies, Monoclonal
  • Cytoskeletal Proteins
  • Membrane Glycoproteins
  • Protozoan Proteins