Serotonin syndrome after concomitant treatment with linezolid and meperidine

Clin Infect Dis. 2008 Jan 15;46(2):264-5. doi: 10.1086/524671.

Abstract

Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors. Meperidine blocks the neuronal reuptake of serotonin. Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described. We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / administration & dosage
  • Acetamides / adverse effects*
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / drug therapy
  • Linezolid
  • Male
  • Meperidine / administration & dosage
  • Meperidine / adverse effects*
  • Oxazolidinones / administration & dosage
  • Oxazolidinones / adverse effects*
  • Serotonin Syndrome / chemically induced*
  • Serotonin Syndrome / complications

Substances

  • Acetamides
  • Oxazolidinones
  • Meperidine
  • Linezolid