The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition

Amino Acids. 2008 May;34(4):547-54. doi: 10.1007/s00726-007-0008-3. Epub 2008 Jan 4.


Carnosine (Carn) occurs in high concentrations in skeletal muscle is a potent physico-chemical buffer of H+ over the physiological range. Recent research has demonstrated that 6.4 g x day(-1) of beta-alanine (beta-ala) can significantly increase skeletal muscle Carn concentrations (M-[Carn]) whilst the resultant change in buffering capacity has been shown to be paralleled by significant improvements in anaerobic and aerobic measures of exercise performance. Muscle carnosine increase has also been linked to increased work done during resistance training. Prior research has suggested that strength training may also increase M-[Carn] although this is disputed by other studies. The aim of this investigation is to assess the effect of 10 weeks resistance training on M-[Carn], and, secondly, to investigate if increased M-[Carn] brought about through beta-ala supplementation had a positive effect on training responses. Twenty-six Vietnamese sports science students completed the study. The subjects completed a 10-week resistance-training program whilst consuming 6.4 g x day(-1) of beta-ala (beta-ALG) or a matched dose of a placebo (PLG). Subjects were assessed prior to and after training for whole body strength, isokinetic force production, muscular endurance, body composition. beta-Alanine supplemented subjects increased M-[Carn] by 12.81 +/- 7.97 mmol x kg(-1) dry muscle whilst there was no change in PLG subjects. There was no significant effect of beta-ala supplementation on any of the exercise parameters measured, mass or % body fat. In conclusion, 10 weeks of resistance training alone did not change M-[Carn].

MeSH terms

  • Adult
  • Analysis of Variance
  • Body Composition / drug effects
  • Body Composition / physiology
  • Carnosine / biosynthesis
  • Dietary Supplements*
  • Exercise*
  • Humans
  • Isotonic Contraction / drug effects
  • Isotonic Contraction / physiology
  • Male
  • Muscle Strength / drug effects
  • Muscle Strength / physiology
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / metabolism
  • Physical Education and Training / methods*
  • Physical Endurance / drug effects
  • Physical Endurance / physiology
  • Placebos
  • Reference Values
  • Sensitivity and Specificity
  • Time Factors
  • beta-Alanine / administration & dosage*


  • Placebos
  • beta-Alanine
  • Carnosine