Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 27 (1), 85-94

The Met Tyrosine Kinase Receptor in Development and Cancer

Affiliations
Review

The Met Tyrosine Kinase Receptor in Development and Cancer

Alessandra Gentile et al. Cancer Metastasis Rev.

Abstract

Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met.

Similar articles

See all similar articles

Cited by 119 articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback