Inhibitory ligand-gated ion channels as substrates for general anesthetic actions

Handb Exp Pharmacol. 2008;(182):31-51. doi: 10.1007/978-3-540-74806-9_2.

Abstract

General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)(A) receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.

Publication types

  • Review

MeSH terms

  • Anesthetics, General / adverse effects
  • Anesthetics, General / pharmacology*
  • Animals
  • Central Nervous System / drug effects*
  • Central Nervous System / metabolism
  • Consciousness / drug effects*
  • Dose-Response Relationship, Drug
  • Humans
  • Ion Channel Gating / drug effects*
  • Ion Channels / drug effects*
  • Ion Channels / genetics
  • Ion Channels / metabolism
  • Mice
  • Mice, Transgenic
  • Mutation
  • Receptors, GABA-A / drug effects*
  • Receptors, GABA-A / genetics
  • Receptors, GABA-A / metabolism
  • Receptors, Glycine / drug effects*
  • Receptors, Glycine / genetics
  • Receptors, Glycine / metabolism

Substances

  • Anesthetics, General
  • Ion Channels
  • Receptors, GABA-A
  • Receptors, Glycine