Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents
- PMID: 18177007
- DOI: 10.1021/np068050q
Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents
Abstract
An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.
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