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. 2008 Jan;71(1):130-3.
doi: 10.1021/np068050q. Epub 2008 Jan 5.

Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

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Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents

George R Pettit et al. J Nat Prod. 2008 Jan.

Abstract

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

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