Non-visual photoreception: sensing light without sight

Curr Biol. 2008 Jan 8;18(1):R38-9. doi: 10.1016/j.cub.2007.11.027.


Recent work in blind human subjects has confirmed the presence of a non-visual ocular photoreceptive mechanism similar to that described in blind mice. This system appears to subserve circadian photic entrainment, the pupillary light response, and a number of other aspects of neurophysiology and behavior.

Publication types

  • Comment

MeSH terms

  • Blindness / physiopathology
  • Circadian Rhythm
  • Humans
  • Light Signal Transduction / physiology*
  • Light*
  • Retinal Ganglion Cells / physiology
  • Rod Opsins / physiology


  • Rod Opsins
  • melanopsin