[Antimicrobial susceptibility of 80 Moraxella catarrhalis strains isolated in the children's hospital of Tunis]

Pathol Biol (Paris). 2008 May;56(3):158-61. doi: 10.1016/j.patbio.2007.09.021. Epub 2008 Jan 4.
[Article in French]

Abstract

Eighty non-repetitive strains of Moraxella catarrhalis, isolated in Tunis Children's Hospital during five years from 1998 to 2002, were tested for their antimicrobial susceptibility, 95% of these strains were isolated from lung samples: 57.5% from trachea products, 35% from sputum and 2.5% from bronchial washings. The majority of strains (72%) were obtained from children under two years old. Antimicrobial susceptibility study showed that 95% of stains were beta-lactamase-producing, therefore they were penicillin G and amoxicillin resistant with high MICs. MIC(90) of penicillin G and amoxicillin of beta-lactamase-producing strains were respectively greater than 32 and 6 mg/l, these MIC decrease with addition of clavulanic acid. In fact, all strains studied were susceptible to the association amoxicillin-clavulanic acid as well as to cefotaxime. Concerning the other antimicrobial groups percentages of resistant strains found were as follows: erythromycin 3.75%, trimethoprim-sulfamethoxazol 12.5% and tetracycline 1.25%. Finally, all strains were susceptible to chloramphenicol, rifampicin and ciprofloxacin.

MeSH terms

  • Amoxicillin / pharmacology
  • Amoxicillin / therapeutic use
  • Child
  • Clavulanic Acid / pharmacology
  • Clavulanic Acid / therapeutic use
  • Hospitals, Pediatric
  • Humans
  • Lung / microbiology
  • Microbial Sensitivity Tests
  • Moraxella catarrhalis / drug effects*
  • Moraxella catarrhalis / isolation & purification
  • Moraxellaceae Infections / epidemiology*
  • Trachea / microbiology
  • Tunisia

Substances

  • Clavulanic Acid
  • Amoxicillin