Raloxifene effects on thyroid gland morphology in ovariectomized rats

Luiz Felipe Bittencourt de Araujo; Renata Grozovsky; Mônica de Campos Pinheiro; Jorge José de Carvalho; Mário Vaisman; Denise P Carvalho

doi:10.1016/j.fertnstert.2007.10.046

Raloxifene effects on thyroid gland morphology in ovariectomized rats

Fertil Steril. 2008 Oct;90(4):1211-4. doi: 10.1016/j.fertnstert.2007.10.046. Epub 2008 Jan 7.

Authors

Luiz Felipe Bittencourt de Araujo¹, Renata Grozovsky, Mônica de Campos Pinheiro, Jorge José de Carvalho, Mário Vaisman, Denise P Carvalho

Affiliation

¹ Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. lfbita@gmail.com

PMID: 18178201
DOI: 10.1016/j.fertnstert.2007.10.046

Abstract

We aimed to analyze the effects of raloxifene and estrogen on thyroid gland morphology of ovariectomized rats. Raloxifene treatment led to effects similar to those of estrogen on thyroid glands from ovariectomized rats, so that both were able to normalize the changes detected after ovariectomy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dose-Response Relationship, Drug
Estrogens / administration & dosage*
Female
Organ Size / drug effects
Ovariectomy*
Raloxifene Hydrochloride / administration & dosage*
Rats
Rats, Wistar
Selective Estrogen Receptor Modulators / administration & dosage
Thyroid Gland / anatomy & histology*
Thyroid Gland / drug effects*

Substances

Estrogens
Selective Estrogen Receptor Modulators
Raloxifene Hydrochloride