Effect of pentagastrin, histalog, glucagon, secretin, and perchlorate on the gastric handling of 99mTc pertechnetate in mice

Radiology. 1976 Sep;120(3):629-31. doi: 10.1148/120.3.629.


Pentagastrin, histalog, glucagon, secretin, and perchlorate were intravenously injected into mice in order to investigate the hormonal regulation of 99mTc pertechnetate uptake by gastric mucosa. Pentagastrin significantly increased uptake; the effect of histalog was weaker. Secretin did not alter the uptake. Glucagon produced some diminution, and perchlorate significantly inhibited gastric uptake. Hormones may play a role in improving the sensitivity and specificity of diagnostic tests for Meckel's diverticulum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Betazole / pharmacology
  • Female
  • Gastric Mucosa / metabolism*
  • Glucagon / pharmacology
  • Male
  • Mice
  • Pentagastrin / pharmacology*
  • Perchlorates / pharmacology
  • Scintillation Counting
  • Secretin / pharmacology
  • Technetium / administration & dosage
  • Technetium / metabolism*


  • Perchlorates
  • Secretin
  • Betazole
  • Technetium
  • Glucagon
  • Pentagastrin