A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis

J Infect Dis. 2008 Jan 15;197(2):266-9. doi: 10.1086/524709.


Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5Delta32 genotyping was performed among Lithuanian patients with TBE (n=129) or with aseptic meningoencephalitis (n=76) as well as among control subjects (n=134). We found individuals homozygous for CCR5Delta32 (P= .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5Delta32 allele prevalence also increased with the clinical severity of disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Encephalitis, Tick-Borne / epidemiology
  • Encephalitis, Tick-Borne / genetics*
  • Encephalitis, Tick-Borne / physiopathology
  • Gene Deletion*
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Homozygote
  • Humans
  • Lithuania / epidemiology
  • Meningoencephalitis / genetics
  • Receptors, CCR5 / genetics*
  • Severity of Illness Index


  • Receptors, CCR5