Circulating fibrocytes: cellular basis for NSF

J Am Coll Radiol. 2008 Jan;5(1):36-9. doi: 10.1016/j.jacr.2007.08.016.


Since the discovery of the circulating fibrocyte as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell population has grown steadily. The present review summarizes the known biology of fibrocytes and discusses evidence for their role in the pathogenesis of nephrogenic systemic fibrosis. Possible mechanisms by which gadolinium may influence the activation or trafficking properties of fibrocytes leading to tissue fibrosis are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Connective Tissue / pathology*
  • Contrast Media / adverse effects*
  • Fibroblasts / physiology*
  • Fibrosis / chemically induced
  • Fibrosis / pathology
  • Gadolinium / adverse effects*
  • Humans
  • Magnetic Resonance Imaging
  • Renal Insufficiency / complications
  • Skin / drug effects
  • Skin / pathology
  • Skin Diseases / chemically induced*
  • Skin Diseases / pathology*


  • Contrast Media
  • Gadolinium