Abstract
The genetic relatedness of ciprofloxacin-resistant Streptococcus pneumoniae isolates collected from 1997 to 2002 (n = 82) and 2003 to 2005 (n = 123) was compared by pulsed-field gel electrophoresis (PFGE). Increased genetic homogeneity among the isolates from 2003 to 2005 (cluster analysis; P < 0.001) appeared to be due to expansion of existing clonal groups and to introduction of new PFGE types.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-Infective Agents / pharmacology*
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Canada / epidemiology
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Child
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Ciprofloxacin / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Drug Resistance, Bacterial / genetics*
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Electrophoresis, Gel, Pulsed-Field
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Female
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Humans
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Infant
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Male
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Microbial Sensitivity Tests / standards
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Middle Aged
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Molecular Epidemiology
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Mutation
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Pneumococcal Infections / epidemiology*
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Pneumococcal Infections / microbiology
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / genetics
Substances
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Anti-Infective Agents
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Ciprofloxacin
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DNA Topoisomerase IV
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DNA Gyrase